Thymosin β-4 · 10 mg / vial- ·3 mL bacteriostatic water
- ·10 × 1 mL insulin syringes
- ·Alcohol swabs
TB-500 10 mg
Synthetic thymosin β-4 — 43-residue actin-sequestering peptide.
Synthetic full-length 43-residue thymosin β-4. The most abundant intracellular actin-sequestering peptide in mammalian tissues.
What the peptide is.
TB-500 denotes synthetic thymosin β-4 (Tβ4), a naturally occurring 43-amino-acid peptide. It is among the most abundant intracellular proteins, functioning primarily as a G-actin sequestering molecule that regulates actin polymerisation and cell motility.
RegeneRx Biopharmaceuticals has developed synthetic Tβ4 under the code RGN-259 through Phase 2 trials in dry-eye disease and neurotrophic keratopathy.
G-actin sequestration → cytoskeletal dynamics. Secondary: integrin-linked kinase upregulation, laminin-5 expression modulation.
Reconstitution, storage, and handling.
Lab-technical guidance for the researcher handling the material. Not therapeutic dosing, not administration guidance — those are not within the scope of this supply.
- Recommended solvent
- Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
- Typical volume
- 1 – 2 mL
- Inject diluent slowly down the side of the vial onto the cake.
- Swirl gently — do not shake.
- Solution should be clear and colourless. Discard if not.
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life · sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
- Shelf life · reconstituted
- Up to 4 weeks refrigerated.
- ▸Amber glass vial, argon-purged. Robust lyophilised stability.
This lot, documented.
Every shipment is accompanied by a signed four-page analytical report including the HPLC chromatogram, ESI-MS spectrum, purity calculation, and sample handling chain-of-custody.
The report you will receive is specific to the lot dispatched to you. The display below is a current representative example.
04:22:11▸lot 26-04-A received ┈ 5.00 g04:22:40▸weight check ┈ PASS ±0.4 mg04:23:12▸sample → janoshik ┈ 50 mg04:23:12▸tracking #jnk-921833405:18:03▸HPLC result ┈ 99.24 %05:18:04▸MS obs 4729.42 Da ┈ PASS05:18:05▸coa.pdf signed ┈ attached05:18:06▸lot approved ┈ LIVE
REPORT ID JA-26-04-012
SUBJECT TB-500 10 mg
DESIGNATION Thymosin β-4
LOT 26-04-A
METHOD RP-HPLC, ESI-MS
COLUMN C18, 250 x 4.6 mm, 5 um
MOBILE PHASE A: 0.1% TFA in H2O
B: 0.1% TFA in ACN
GRADIENT 5 -> 65% B over 20 min
FLOW RATE 1.0 mL/min
DETECTION UV 214 nm
INJECTION 20 uL @ 0.5 mg/mL
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PURITY (A%) 99.10
MASS EXP. 4963.40 Da
MASS OBS. 4963.42 Da
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CONCLUSION Identity CONFIRMED · Purity PASS
SIGNED BY J. Novak, MSc · Janoshik Analytical SVK
DATE 2026-04-11Registered clinical investigation.
Links below resolve to the ClinicalTrials.gov registry. Trial status reflects publicly disclosed information at the time of publication.
| NCT | Phase | Title | Status | |
|---|---|---|---|---|
| NCT02623244 | Phase 3 | ARISE-3: RGN-259 in dry eye | Completed | Registry ↗ |
Research references for TB-500 10 mg.
2 peer-reviewed publications. Links resolve to PubMed. DOIs are provided where available.
- [01]Goldstein AL, Hannappel E, Sosne G, Kleinman HK
Thymosin β4: a multi-functional regenerative peptide
Expert Opinion on Biological Therapy · 2012 - [02]Sosne G, Ousler GW
Thymosin beta 4 ophthalmic solution for dry eye — Phase 2
Clinical Ophthalmology · 2015
- Q.Is this the same as the short Ac-SDKP tetrapeptide?
- A.No. Full 43-residue Tβ4. Ac-SDKP (goralatide) is a separate N-terminal tetrapeptide with distinct activity.
This peptide is supplied by Omega Grade for in vitro laboratory research use. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA, EMA, MHRA, PMDA, or any other regulatory authority for any therapeutic indication.
No claim of therapeutic benefit is made or implied. The material is not intended for human or veterinary consumption, administration, or any form of self-experimentation. By purchasing, you acknowledge the researcher terms and accept full responsibility for local import compliance and all handling.
Often considered alongside.
BPC-157 + TB-500 10/10 mg kit
Paired regenerative peptides — combined kit, most-requested blend.
- Form
- Lyophilised kit
- Dose
- 10 mg BPC-157 + 10 mg TB-500 / vial
- Purity
- ≥ 99.0% (both peptides)
BPC-157 15 mg
Pentadecapeptide — 15-residue fragment of a gastric body-protection protein.
- Form
- Lyophilised kit
- Dose
- 15 mg / vial
- Purity
- ≥ 99.4%
BPC-157 + TB-500 20/20 mg pen
High-dose pen format — 20 mg BPC-157 + 20 mg TB-500.
- Form
- Pre-filled pen
- Dose
- 20 mg BPC-157 + 20 mg TB-500 (pre-filled pen)
- Purity
- ≥ 99.0%