Mitochondrial ORF-12S peptide · 40 mg / vial- ·3 mL bacteriostatic water
- ·10 × 1 mL insulin syringes
- ·Alcohol swabs
MOTS-c 40 mg
Mitochondrial-derived 16-residue peptide — high-dose kit.
MOTS-c is a 16-residue peptide encoded in the mitochondrial 12S rRNA region. Described by the Cohen lab in 2015 — studied in metabolic and exercise biology.
What the peptide is.
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is one of the best-characterised mitochondrial-derived peptides. First described by the Cohen laboratory at USC in 2015 (Cell Metabolism).
Studied in metabolic regulation, insulin sensitivity, exercise physiology, and age-related decline — predominantly in preclinical models and observational human cohort studies.
Proposed: AMPK activation, folate-cycle regulation, nuclear translocation under metabolic stress, modulation of insulin sensitivity in skeletal muscle.
Reconstitution, storage, and handling.
Lab-technical guidance for the researcher handling the material. Not therapeutic dosing, not administration guidance — those are not within the scope of this supply.
- Recommended solvent
- Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
- Typical volume
- 1 – 2 mL
- Inject diluent slowly down the side of the vial onto the cake.
- Swirl gently — do not shake.
- Solution should be clear and colourless. Discard if not.
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life · sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
- Shelf life · reconstituted
- Up to 4 weeks refrigerated.
- ▸Methionine-rich — avoid oxidising conditions.
This lot, documented.
Every shipment is accompanied by a signed four-page analytical report including the HPLC chromatogram, ESI-MS spectrum, purity calculation, and sample handling chain-of-custody.
The report you will receive is specific to the lot dispatched to you. The display below is a current representative example.
04:22:11▸lot 26-04-A received ┈ 5.00 g04:22:40▸weight check ┈ PASS ±0.4 mg04:23:12▸sample → janoshik ┈ 50 mg04:23:12▸tracking #jnk-921833405:18:03▸HPLC result ┈ 99.24 %05:18:04▸MS obs 4729.42 Da ┈ PASS05:18:05▸coa.pdf signed ┈ attached05:18:06▸lot approved ┈ LIVE
REPORT ID JA-26-04-012
SUBJECT MOTS-c 40 mg
DESIGNATION Mitochondrial ORF-12S peptide
LOT 26-04-A
METHOD RP-HPLC, ESI-MS
COLUMN C18, 250 x 4.6 mm, 5 um
MOBILE PHASE A: 0.1% TFA in H2O
B: 0.1% TFA in ACN
GRADIENT 5 -> 65% B over 20 min
FLOW RATE 1.0 mL/min
DETECTION UV 214 nm
INJECTION 20 uL @ 0.5 mg/mL
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PURITY (A%) 99.00
MASS EXP. 1888.30 Da
MASS OBS. 1888.32 Da
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CONCLUSION Identity CONFIRMED · Purity PASS
SIGNED BY J. Novak, MSc · Janoshik Analytical SVK
DATE 2026-04-11Research references for MOTS-c 40 mg.
2 peer-reviewed publications. Links resolve to PubMed. DOIs are provided where available.
- [01]Lee C, Zeng J, Drew BG, et al.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis
Cell Metabolism · 2015 - [02]Reynolds JC, Lai RW, Woodhead JST, et al.
MOTS-c as an exercise-induced regulator of age-dependent physical decline
Nature Communications · 2021
- Q.Why methionine oxidation caution?
- A.MOTS-c contains two methionines susceptible to oxidation to methionine sulfoxide under warm, humid, or oxidising conditions. Correct cold-dry storage maintains integrity.
This peptide is supplied by Omega Grade for in vitro laboratory research use. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA, EMA, MHRA, PMDA, or any other regulatory authority for any therapeutic indication.
No claim of therapeutic benefit is made or implied. The material is not intended for human or veterinary consumption, administration, or any form of self-experimentation. By purchasing, you acknowledge the researcher terms and accept full responsibility for local import compliance and all handling.
Often considered alongside.
NAD⁺ 500 mg kit
NAD⁺ coenzyme — 500 mg kit presentation.
- Form
- Lyophilised kit
- Dose
- 500 mg / vial
- Purity
- ≥ 99.0%
NAD⁺ 1000 mg pen
High-dose NAD⁺ pen — 1000 mg pre-reconstituted.
- Form
- Pre-filled pen
- Dose
- 1000 mg / pen
- Purity
- ≥ 99.0%
5-Amino-1MQ 5 mg
NNMT inhibitor — small-molecule metabolic research tool.
- Form
- Lyophilised kit
- Dose
- 5 mg / vial
- Purity
- ≥ 99.0%