5-Amino-1-methylquinolinium · 5 mg / vial- ·3 mL bacteriostatic water
- ·10 × 1 mL insulin syringes
- ·Alcohol swabs
5-Amino-1MQ 5 mg
NNMT inhibitor — small-molecule metabolic research tool.
5-Amino-1-methylquinolinium — a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in metabolic and adipose-tissue research.
What the peptide is.
5-Amino-1MQ is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase), the enzyme that methylates nicotinamide using SAM as methyl donor. NNMT is upregulated in adipose tissue in obesity; inhibition has been studied as a metabolic-research tool.
Published in 2018 by Neelakantan and colleagues. Purely preclinical at this stage.
Competitive inhibition of NNMT → altered SAM / nicotinamide balance → downstream effects on adipose-tissue energy metabolism.
Reconstitution, storage, and handling.
Lab-technical guidance for the researcher handling the material. Not therapeutic dosing, not administration guidance — those are not within the scope of this supply.
- Recommended solvent
- Sterile water or DMSO (for cell-culture stock)
- Typical volume
- 1 – 2 mL
- Small molecule — readily soluble.
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life · sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
- Shelf life · reconstituted
- Up to 4 weeks refrigerated.
- ▸Small molecule — different handling from peptide reagents.
This lot, documented.
Every shipment is accompanied by a signed four-page analytical report including the HPLC chromatogram, ESI-MS spectrum, purity calculation, and sample handling chain-of-custody.
The report you will receive is specific to the lot dispatched to you. The display below is a current representative example.
04:22:11▸lot 26-04-A received ┈ 5.00 g04:22:40▸weight check ┈ PASS ±0.4 mg04:23:12▸sample → janoshik ┈ 50 mg04:23:12▸tracking #jnk-921833405:18:03▸HPLC result ┈ 99.24 %05:18:04▸MS obs 4729.42 Da ┈ PASS05:18:05▸coa.pdf signed ┈ attached05:18:06▸lot approved ┈ LIVE
REPORT ID JA-26-04-012
SUBJECT 5-Amino-1MQ 5 mg
DESIGNATION 5-Amino-1-methylquinolinium
LOT 26-04-A
METHOD RP-HPLC, ESI-MS
COLUMN C18, 250 x 4.6 mm, 5 um
MOBILE PHASE A: 0.1% TFA in H2O
B: 0.1% TFA in ACN
GRADIENT 5 -> 65% B over 20 min
FLOW RATE 1.0 mL/min
DETECTION UV 214 nm
INJECTION 20 uL @ 0.5 mg/mL
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PURITY (A%) 99.00
MASS EXP. 159.21 Da
MASS OBS. 159.23 Da
---
CONCLUSION Identity CONFIRMED · Purity PASS
SIGNED BY J. Novak, MSc · Janoshik Analytical SVK
DATE 2026-04-11Research references for 5-Amino-1MQ 5 mg.
1 peer-reviewed publications. Links resolve to PubMed. DOIs are provided where available.
- [01]Neelakantan H, Vance V, Wetzel MD, et al.
Selective and membrane-permeable small molecule inhibitors of NNMT — 5-amino-1-methylquinolinium
Biochemical Pharmacology · 2018
- Q.Why isn't this a peptide?
- A.It is a small molecule — a methylated quinolinium derivative. Included because it is commonly used alongside mitochondrial peptides in metabolic research.
This peptide is supplied by Omega Grade for in vitro laboratory research use. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA, EMA, MHRA, PMDA, or any other regulatory authority for any therapeutic indication.
No claim of therapeutic benefit is made or implied. The material is not intended for human or veterinary consumption, administration, or any form of self-experimentation. By purchasing, you acknowledge the researcher terms and accept full responsibility for local import compliance and all handling.
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