MOTS-c 40 mg
Also known as · Mitochondrial ORF-12S peptide
MOTS-c is a 16-residue peptide encoded in the mitochondrial 12S rRNA region. Described by the Cohen lab in 2015 — studied in metabolic and exercise biology.
Chemistry quick-facts
- Formula
- C79H133N23O24S3
- MW
- 1888.3 Da
- Length
- 16 aa
- Status
- Research peptide. No clinical trials. First described in 2015.
- Purity (HPLC)
- ≥ 99.0%
Mechanism of action
Proposed: AMPK activation, folate-cycle regulation, nuclear translocation under metabolic stress, modulation of insulin sensitivity in skeletal muscle.
Research context
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is one of the best-characterised mitochondrial-derived peptides. First described by the Cohen laboratory at USC in 2015 (Cell Metabolism).
Studied in metabolic regulation, insulin sensitivity, exercise physiology, and age-related decline — predominantly in preclinical models and observational human cohort studies.
Published studies
A non-exhaustive list of peer-reviewed studies referenced when curating this entry. Click through to the primary source for the full text.
- Lee C, Zeng J, Drew BG, et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metabolism.
- Reynolds JC, Lai RW, Woodhead JST, et al. (2021). MOTS-c as an exercise-induced regulator of age-dependent physical decline. Nature Communications.
Reconstitution
- Solvent
- Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
- Typical volume
- 1 – 2 mL
- · Inject diluent slowly down the side of the vial onto the cake.
- · Swirl gently — do not shake.
- · Solution should be clear and colourless. Discard if not.
Storage
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life — sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
FAQ
Why methionine oxidation caution?+
MOTS-c contains two methionines susceptible to oxidation to methionine sulfoxide under warm, humid, or oxidising conditions. Correct cold-dry storage maintains integrity.
This page summarises the research literature on MOTS-c 40 mg for in vitro laboratory investigation only. It is not medical advice, not a treatment recommendation, and not a substitute for a qualified physician. Material is sold for analytical chemistry and cell-culture research, not for human or veterinary administration.
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