5-Amino-1MQ 5 mg
Also known as · 5-Amino-1-methylquinolinium
5-Amino-1-methylquinolinium — a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in metabolic and adipose-tissue research.
Chemistry quick-facts
- CAS
- 50478-35-0
- Formula
- C10H11N2⁺
- MW
- 159.21 Da
- Status
- Preclinical research tool. No clinical trials. Small molecule, not a peptide.
- Purity (HPLC)
- ≥ 99.0%
Mechanism of action
Competitive inhibition of NNMT → altered SAM / nicotinamide balance → downstream effects on adipose-tissue energy metabolism.
Research context
5-Amino-1MQ is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase), the enzyme that methylates nicotinamide using SAM as methyl donor. NNMT is upregulated in adipose tissue in obesity; inhibition has been studied as a metabolic-research tool.
Published in 2018 by Neelakantan and colleagues. Purely preclinical at this stage.
Published studies
A non-exhaustive list of peer-reviewed studies referenced when curating this entry. Click through to the primary source for the full text.
- Neelakantan H, Vance V, Wetzel MD, et al. (2018). Selective and membrane-permeable small molecule inhibitors of NNMT — 5-amino-1-methylquinolinium. Biochemical Pharmacology.
Reconstitution
- Solvent
- Sterile water or DMSO (for cell-culture stock)
- Typical volume
- 1 – 2 mL
- · Small molecule — readily soluble.
Storage
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life — sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
FAQ
Why isn't this a peptide?+
It is a small molecule — a methylated quinolinium derivative. Included because it is commonly used alongside mitochondrial peptides in metabolic research.
This page summarises the research literature on 5-Amino-1MQ 5 mg for in vitro laboratory investigation only. It is not medical advice, not a treatment recommendation, and not a substitute for a qualified physician. Material is sold for analytical chemistry and cell-culture research, not for human or veterinary administration.
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