Melanotan I 10 mg
Also known as · MT-1 · Afamelanotide · Nle⁴-D-Phe⁷-α-MSH
Afamelanotide — linear α-MSH analogue with enhanced metabolic stability. Approved clinically for a rare photosensitivity indication.
Chemistry quick-facts
- CAS
- 75921-69-6
- Formula
- C78H111N21O19
- MW
- 1646.87 Da
- Length
- 13 aa
- Status
- Afamelanotide (MT-1) is approved by the EMA and FDA for erythropoietic protoporphyria (EPP) under the trade name Scenesse®. Omega Grade supplies research-grade peptide only.
- Purity (HPLC)
- ≥ 99.0%
Mechanism of action
Selective agonism at MC1R. Stimulates eumelanogenesis in epidermal melanocytes.
Research context
Afamelanotide (MT-1) is a synthetic 13-amino-acid linear analogue of α-MSH. The Nle⁴ and D-Phe⁷ substitutions confer resistance to enzymatic degradation.
The clinical product Scenesse® (subcutaneous implant) is approved in the EU and US for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP).
Omega Grade supplies lyophilised research-grade peptide — not the clinical implant formulation.
Published studies
A non-exhaustive list of peer-reviewed studies referenced when curating this entry. Click through to the primary source for the full text.
- Langendonk JG, Balwani M, Anderson KE, et al. (2015). Afamelanotide for Erythropoietic Protoporphyria. New England Journal of Medicine.
Reconstitution
- Solvent
- Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
- Typical volume
- 1 – 2 mL
- · Inject diluent slowly down the side of the vial onto the cake.
- · Swirl gently — do not shake.
- · Solution should be clear and colourless. Discard if not.
Storage
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life — sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
FAQ
What is the difference between MT-1 and MT-2?+
MT-1 (afamelanotide) is a linear, MC1R-selective analogue that reached clinical approval for EPP. MT-2 is a cyclic, non-selective melanocortin-receptor agonist for research only.
This page summarises the research literature on Melanotan I 10 mg for in vitro laboratory investigation only. It is not medical advice, not a treatment recommendation, and not a substitute for a qualified physician. Material is sold for analytical chemistry and cell-culture research, not for human or veterinary administration.
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Melanotan II is a synthetic cyclic heptapeptide non-selective melanocortin-receptor agonist (MC1R / MC3R / MC4R / MC5R).
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