HOMA-IR
A calculated index of insulin resistance from fasting glucose × fasting insulin.
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) = (fasting glucose mmol/L × fasting insulin µIU/mL) / 22.5. It estimates insulin resistance from a single fasting blood draw without requiring an oral glucose tolerance test. Validated against gold-standard euglycaemic clamp (correlation ~0.85+). Crucially, HOMA-IR can rise years before HbA1c moves out of normal range — a sensitive early-warning signal for the metabolic-syndrome trajectory that most GP panels miss because they don't include fasting insulin.
- GlossaryCOA (Certificate of Analysis)
Document showing the analytical results — typically purity, mass, and identity — for a specific batch of research peptide.
- GlossaryHPLC
High-performance liquid chromatography — the standard purity assay for research peptides.
- GlossaryMass spectrometry
Identifies a compound by measuring its mass-to-charge ratio.
- BiomarkerHOMA-IR 2.5
HOMA-IR is a calculated index from fasting glucose × fasting insulin. A HOMA-IR of 2.5 sits at the threshold most metabolic research uses for early insulin resistance, often years before HbA1c shifts.