Incretin
Gut-derived hormones (GLP-1, GIP) that stimulate post-meal insulin secretion.
Incretins are gut hormones secreted in response to nutrient ingestion that augment glucose-dependent insulin secretion from pancreatic β-cells. The two principal incretins are GLP-1 (from intestinal L-cells) and GIP (from intestinal K-cells). The 'incretin effect' — the observation that oral glucose produces a much larger insulin response than intravenous glucose at matched plasma levels — is mediated by these hormones. Incretin-based research compounds form one of the largest classes of metabolic-disease drugs (semaglutide, liraglutide, dulaglutide, tirzepatide, retatrutide).
- GlossaryGLP-1
Glucagon-like peptide-1, an incretin hormone that regulates glucose and appetite.
- GlossaryGIP
Glucose-dependent insulinotropic polypeptide, an incretin hormone with metabolic and adipose effects.
- GlossaryGHRH
Growth hormone-releasing hormone, the hypothalamic peptide that triggers GH release.
- ResearchRetatrutide 30 mg kit
Retatrutide 30 mg lyophilised vial kit — the mid-dose research presentation. Includes bacteriostatic water, syringes, and swabs.
- ResearchMOTS-c 40 mg
MOTS-c is a 16-residue peptide encoded in the mitochondrial 12S rRNA region. Described by the Cohen lab in 2015 — studied in metabolic and exercise bi