Sirtuin
A family of NAD+-dependent deacetylase enzymes implicated in longevity and metabolic regulation.
Sirtuins are a family of seven NAD+-dependent deacetylases (SIRT1 through SIRT7) found across all kingdoms of life. They remove acetyl groups from histones and other proteins, regulating gene expression, mitochondrial biogenesis, autophagy, and DNA repair. SIRT1 in particular is a central node in the longevity research literature — it senses cellular NAD+ availability and modulates downstream pathways including FOXO transcription factors and PGC-1α (mitochondrial biogenesis). Sirtuin activity declines with age in lockstep with NAD+ decline, which is the mechanistic basis for NAD+ precursor supplementation research.
- ResearchNAD⁺ 500 mg kit
Nicotinamide adenine dinucleotide — the coenzyme central to cellular electron-transfer, sirtuin signalling, and redox biology.
- ResearchMOTS-c 40 mg
MOTS-c is a 16-residue peptide encoded in the mitochondrial 12S rRNA region. Described by the Cohen lab in 2015 — studied in metabolic and exercise bi
- ResearchNAD⁺ 1000 mg pen
High-dose pen format NAD⁺ — double the 500 mg vial kit, in a pre-filled pen device.
- GlossaryGLP-1
Glucagon-like peptide-1, an incretin hormone that regulates glucose and appetite.
- GlossaryGIP
Glucose-dependent insulinotropic polypeptide, an incretin hormone with metabolic and adipose effects.