CJC-1295 with DAC 5 mg
Also known as · CJC-1295 DAC · GRF-29 DAC
CJC-1295 with Drug Affinity Complex (DAC) — an extended GHRH analogue designed for half-life extension through covalent albumin binding.
Chemistry quick-facts
- CAS
- 863288-34-0
- Formula
- C165H269N47O46
- MW
- 3647.28 Da
- Length
- 30 aa
- Status
- Investigational. Phase 1 / 2 trials by ConjuChem (discontinued). Not approved.
- Purity (HPLC)
- ≥ 99.0%
Mechanism of action
Stimulates GH release via pituitary GHRH receptor. Albumin covalent binding extends plasma residence time.
Research context
CJC-1295 is a 30-residue GHRH analogue developed by ConjuChem. The DAC (Drug Affinity Complex) variant incorporates a maleimidopropionic acid linker enabling covalent binding to serum albumin, dramatically extending half-life relative to native GHRH.
Clinical development was discontinued; widely used in preclinical GH-axis research today.
Published studies
A non-exhaustive list of peer-reviewed studies referenced when curating this entry. Click through to the primary source for the full text.
- Teichman SL, Neale A, Lawrence B, et al. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295. Journal of Clinical Endocrinology & Metabolism.
Reconstitution
- Solvent
- Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
- Typical volume
- 1 – 2 mL
- · Inject diluent slowly down the side of the vial onto the cake.
- · Swirl gently — do not shake.
- · Solution should be clear and colourless. Discard if not.
Storage
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life — sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
FAQ
What is the difference between CJC-1295 with and without DAC?+
The DAC variant includes a maleimidopropionic acid (MPA) linker that covalently binds to serum albumin, extending plasma half-life to ~6–8 days. The non-DAC form has a half-life of ~30 minutes. Both are used in preclinical research.
This page summarises the research literature on CJC-1295 with DAC 5 mg for in vitro laboratory investigation only. It is not medical advice, not a treatment recommendation, and not a substitute for a qualified physician. Material is sold for analytical chemistry and cell-culture research, not for human or veterinary administration.
- ResearchIpamorelin 10 mg
Ipamorelin is a selective ghrelin-receptor (GHSR) agonist. One of the cleanest pharmacological profiles in the growth-hormone-secretagogue class.
- ResearchCJC-1295 no DAC 10 mg
CJC-1295 without DAC — short-acting modified GRF(1-29). Commonly used in preclinical GH-pulse research alongside ipamorelin.
- ResearchSermorelin 10 mg
Sermorelin is the 29-amino-acid N-terminal fragment of GHRH — the minimum sequence for full GH-releasing activity.
- GlossaryGHRH
Growth hormone-releasing hormone, the hypothalamic peptide that triggers GH release.
- GlossaryIGF-1
Insulin-like growth factor 1 — the main downstream mediator of growth hormone effects.
- GlossaryGHS receptor (GHSR-1a)
The growth-hormone secretagogue receptor — also called the ghrelin receptor.