GHS receptor (GHSR-1a)
The growth-hormone secretagogue receptor — also called the ghrelin receptor.
GHSR-1a is the G-protein-coupled receptor that binds ghrelin (the endogenous hunger hormone) and synthetic growth-hormone secretagogues (GHS) including ipamorelin, GHRP-2, GHRP-6, hexarelin, and the orally-active MK-677 (ibutamoren). Activation triggers immediate GH release from pituitary somatotrophs. The receptor is also expressed in the hypothalamus (appetite) and across cardiovascular tissues — which explains why some early GHS compounds (hexarelin, GHRP-2) had unwanted appetite and cardiovascular effects. Ipamorelin was specifically engineered for GHSR-1a selectivity to minimise cross-reactivity.
- ResearchIpamorelin 10 mg
Ipamorelin is a selective ghrelin-receptor (GHSR) agonist. One of the cleanest pharmacological profiles in the growth-hormone-secretagogue class.
- ResearchCJC-1295 with DAC 5 mg
CJC-1295 with Drug Affinity Complex (DAC) — an extended GHRH analogue designed for half-life extension through covalent albumin binding.
- ResearchCJC-1295 no DAC 10 mg
CJC-1295 without DAC — short-acting modified GRF(1-29). Commonly used in preclinical GH-pulse research alongside ipamorelin.
- GlossaryGLP-1
Glucagon-like peptide-1, an incretin hormone that regulates glucose and appetite.
- GlossaryGIP
Glucose-dependent insulinotropic polypeptide, an incretin hormone with metabolic and adipose effects.