PT-141 10 mg
Also known as · Bremelanotide · Vyleesi® active
PT-141 is bremelanotide — an approved cyclic heptapeptide MC3R/MC4R agonist. The research-grade form is commonly used in receptor-binding and signalling assays.
Chemistry quick-facts
- CAS
- 189691-06-3
- Formula
- C50H68N14O10
- MW
- 1025.19 Da
- Length
- 7 aa
- Status
- Bremelanotide is approved by the FDA (2019) for hypoactive sexual desire disorder in premenopausal women under the trade name Vyleesi®. Supplied by Omega Grade as research-grade peptide.
- Purity (HPLC)
- ≥ 99.0%
Mechanism of action
Non-selective agonism at MC3R and MC4R; weaker MC1R activity relative to MT-II. Central nervous system penetration; downstream signalling through cAMP / PKA.
Research context
PT-141 (bremelanotide) was developed from MT-II and optimised for melanocortin-4 receptor activity while retaining MC3R activity. It is a cyclic seven-residue peptide with enhanced metabolic stability.
FDA approved for hypoactive sexual desire disorder (HSDD) in premenopausal women in 2019 under the brand name Vyleesi®. Omega Grade supplies lyophilised research-grade peptide for in vitro laboratory work, not the clinical formulation.
Published studies
A non-exhaustive list of peer-reviewed studies referenced when curating this entry. Click through to the primary source for the full text.
- Kingsberg SA, Clayton AH, Portman D, et al. (2019). Bremelanotide for Hypoactive Sexual Desire Disorder (RECONNECT). Obstetrics & Gynecology.
- Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB (2004). Double-blind, placebo-controlled evaluation of PT-141 nasal spray in men with ED. International Journal of Impotence Research.
Reconstitution
- Solvent
- Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
- Typical volume
- 1 – 2 mL
- · Inject diluent slowly down the side of the vial onto the cake.
- · Swirl gently — do not shake.
- · Solution should be clear and colourless. Discard if not.
Storage
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life — sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
FAQ
How is this different from Vyleesi®?+
The active peptide is the same (bremelanotide). Vyleesi® is a sterile pre-filled autoinjector for therapeutic use; Omega Grade supplies lyophilised research peptide for laboratory investigation only.
This page summarises the research literature on PT-141 10 mg for in vitro laboratory investigation only. It is not medical advice, not a treatment recommendation, and not a substitute for a qualified physician. Material is sold for analytical chemistry and cell-culture research, not for human or veterinary administration.
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