Semax 11 mg
Also known as · ACTH(4-7)-Pro-Gly-Pro
Semax is a synthetic heptapeptide analogue of ACTH(4-10). Registered in Russia for stroke and cognitive indications; Western research-use only.
Chemistry quick-facts
- CAS
- 80714-61-0
- Formula
- C37H51N9O10S
- MW
- 813.94 Da
- Length
- 7 aa
- Status
- Registered for clinical use in Russia for cognitive and neuroprotective indications. No Western regulatory approval.
- Purity (HPLC)
- ≥ 99.0%
Mechanism of action
Proposed: BDNF / NGF modulation, melanocortin-receptor binding, neuroprotective signalling in preclinical ischaemia models.
Research context
Semax is a synthetic heptapeptide developed at the Institute of Molecular Genetics in Moscow. It comprises residues 4-7 of ACTH followed by the C-terminal Pro-Gly-Pro tripeptide, enhancing enzymatic stability.
Registered in the Russian Federation for ischaemic stroke and cognitive-enhancement indications; not approved in the EU, UK, US, or other Western jurisdictions.
Published studies
A non-exhaustive list of peer-reviewed studies referenced when curating this entry. Click through to the primary source for the full text.
- Dolotov OV, Karpenko EA, Inozemtseva LS, et al. (2006). Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research.
Reconstitution
- Solvent
- Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
- Typical volume
- 1 – 2 mL
- · Inject diluent slowly down the side of the vial onto the cake.
- · Swirl gently — do not shake.
- · Solution should be clear and colourless. Discard if not.
Storage
- Lyophilised
- −20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
- Reconstituted
- 2–8 °C, original vial, consumed within 4 weeks.
- Shelf life — sealed
- 24 months from date of manufacture when stored lyophilised at −20 °C.
FAQ
Where is Semax approved?+
In the Russian Federation only, for specific cognitive and ischaemic-stroke indications. Not approved in the UK, EU, US, or most other jurisdictions.
This page summarises the research literature on Semax 11 mg for in vitro laboratory investigation only. It is not medical advice, not a treatment recommendation, and not a substitute for a qualified physician. Material is sold for analytical chemistry and cell-culture research, not for human or veterinary administration.
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