§ Research summary · Nootropic

DSIP 15 mg

Also known as · Delta Sleep-Inducing Peptide

Nootropic·1 min read·reviewed 2026-05-07

DSIP was isolated from the cerebral venous blood of sleeping rabbits in the 1970s by the Monnier / Schoenenberger group. One of the earliest discovered neuroactive peptides.

Chemistry quick-facts

CAS
62568-57-4
Formula
C35H48N10O15
MW
849.89 Da
Length
9 aa
Status
Preclinical research peptide. No approved clinical indication. Limited human research in sleep-physiology contexts (primarily 1980s European literature).
Purity (HPLC)
≥ 99.0%

Mechanism of action

Not fully characterised. Proposed effects on HPA-axis modulation, antinociception, and delta-wave EEG activity.

Research context

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from the cerebral venous blood of rabbits during electrically induced delta sleep. Despite the name, its role in sleep regulation has not been consistently replicated and its mechanism of action remains incompletely characterised.

Used predominantly in preclinical neurophysiology research.

Published studies

A non-exhaustive list of peer-reviewed studies referenced when curating this entry. Click through to the primary source for the full text.

  1. Graf MV, Kastin AJ (1986). Delta-sleep-inducing peptide (DSIP): an update. Peptides.

Reconstitution

Solvent
Bacteriostatic water for injection (0.9% benzyl alcohol) — included with kit
Typical volume
1 – 2 mL
  • · Inject diluent slowly down the side of the vial onto the cake.
  • · Swirl gently — do not shake.
  • · Solution should be clear and colourless. Discard if not.

Storage

Lyophilised
−20 °C, desiccated, protected from light. Stable at 15–25 °C for up to 30 days in transit.
Reconstituted
2–8 °C, original vial, consumed within 4 weeks.
Shelf life — sealed
24 months from date of manufacture when stored lyophilised at −20 °C.
Research-use disclaimer

This page summarises the research literature on DSIP 15 mg for in vitro laboratory investigation only. It is not medical advice, not a treatment recommendation, and not a substitute for a qualified physician. Material is sold for analytical chemistry and cell-culture research, not for human or veterinary administration.

View DSIP 15 mg in the catalogue →
§ Related reading